最地道的： What's puzzling you most? 希望能帮到您，以后英语方面有什么问题就来找我吧！专业为您翻译多种中英文稿件！ 旺旺：辉哥您好
what's the biggest problem making you in trouble ?
what is the biggest problem is bothering you
"What troubles you most?" (逍遥汉 wrote it) is very good. Or, "What is your biggest problem?"
What do you think is the biggest problem troubles you?
What troubles you most?
Which problem troubles you the most?
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答：去网上看看，肯定有的~~~~~~~~~~~~~~~~~~~~详情>>
