guess: 是凭想象加以猜测。单指猜想简单的东西。如：
guess what i have in my hand.（猜猜，我手里是什么？）
suppose:与think的意思相近，但要比think缺少依据。如：
i do not suppose he will come here.(我想他不会来了。）
答：suppose的深度含有的理性成份大于guess，后者更多的含义局限于随意性上。
the lastest one above me was correct, but there are some more example. suppose, 通常用为 应该怎样怎样，例如： - i was suppose to go to work yesterday but I had a car accident on the way, I took a off. - Those cargo is suppose to be dilivered at 9am, but .... guess, is absolutely means 猜测, 推测 Good luck!
suppose有假设的意思 guess只有猜的意思
对,dalian说的对
"I suppose that... " 更多指“我想，我认为”。 具体用法的选择要看“猜测”所用的语气和上下文。
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